The biochemistry of rapid replication
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51. Genome Replikin Count™ Predicts Increased Infectivity/Lethality of
Viruses April 3, 2012
(From Nature Precedings: doi:10.1038/npre.2012.7144.1 April 2012)


Samuel Bogoch and Elenore S. Bogoch, Foundation for Research on the Nervous System, Boston University School of Medicine, Bioradar UK Ltd, and Replikins Ltd. 36 The Fenway, Boston, MA 02215

Figure 1. Three-Dimensional Visualization of actual amino acids of virus H1N1 hemagglutinin before and during the 2009 H1N1 Pandemic shows the increasing appearance of replikin structures on the surface of the hemagglutinin gene, and the encirclement of the sialic acid contact area of the virus, as the Replikin Counts increased from 3.2 to 10.1 during the Pandemic's development.

Replikins are in cyan. Contact points for the sialic acid host receptor are shown as orange spheres. Note at 3.2 there are no visible replikins around the sialic acid. At 5.5 the partial, and at 10.1 the almost complete encirclement of the sialic acid site by replikins. The maximal surface coverage is achieved at Replikin Count of 10.1; the surface at Replikin Count of 11.7 (not shown) is the same as that at 10.1.
This communication is one of four submitted together:

Genome Replikin Count™ Predicts Increased Lethality of Resistant Tuberculosis
Genome Replikin Count™ Predicts Increased Lethality of Malaria
Genome Replikin Count™ Predicts Increased Lethality of Cancer
Genome Replikin Count™ Predicts Increased Infectivity/Lethality of Virus

Abstract

The genomes of all groups of viruses whose sequences are listed on Pubmed, specimens since 1918, analyzed by a software from Bioradar UK Ltd., contain Replikins which range in concentration from a Replikin Count (number of Replikins per 100 amino acids) of less than 1 to 30 (see accompanying communications for higher Counts in tuberculosis, malaria, and cancer, associated with higher lethality). Counts of less than 4.0 were found in 'resting' virus states; Counts greater than 4.0, found to be associated with rapid replication, were found invariably to accompany or to predict virus outbreaks, by as much as two years, in viral hosts examined from salmon, to birds, to livestock, to humans. X-ray diffraction showed Replikins to be on the surface of the hemagglutinin gene of influenza and to spread as the Count increased from 3.2 to 10.1, prior to, then during, the 2009 H1N1 influenza pandemic. The degree of lethality of these outbreaks was found to be a function of the statistically significant increase in Replikin Count, particularly in the influenza polymerase gene p B1 or its equivalent in other viruses. Prediction up to two years in advance of the outbreak, and the geographic location of the outbreak, now done in 7/7 trials (see Bogoch, Nature Precedings), has permitted the solid phase synthesis of Replikin vaccines in 7 days, with time to permit manufacture, adequate testing for safety and efficacy, and distribution freeze-dried to all populations. These completely synthetic Replikins vaccines so far have been shown to be effective against Taura Syndrome virus in shrimp, and H5N1 in chickens. Thus for the first time this new technology provides the practical possibility to prevent pandemics rather than just to react to them.

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